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hoodia parviflora
- Development stage
- Preclinical
- Lead developer
- Desert Labs
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Hoodia parviflora is a succulent plant native to Southern Africa that is utilized as a botanical extract for metabolic health. Research in animal models of metabolic syndrome and non-alcoholic steatohepatitis (NASH) has demonstrated that oral administration of H. parviflora can improve insulin sensitivity, glucose tolerance, and hepatic histology while reducing liver enzymes and intrahepatic triglycerides. These therapeutic effects are associated with a reduction in proinflammatory markers, including IL-6 secretion and STAT3 signaling, and occur independently of changes in food consumption or body weight. Commercially, it is developed as a dietary supplement and has been granted GRAS (Generally Recognized as Safe) status in the United States.
- Brand names
- Hoodia Parviflora
- Other names
- Hoodia parviflora N.E. Br.
02
Targets
STAT3 (Signal Transducer and Activator of Transcription 3)IL-6 (Interleukin 6)
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