Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
HOP230-245
- Development stage
- Preclinical
- Lead developer
- Northwestern University
- Modality
- Peptides
- Administration
- Intratumoral
01
Overview
HOP230-245 is a synthetic peptide therapeutic designed to disrupt the interaction between the cellular prion protein (PrPC) and the heat shock organizing protein (HOP, also known as STIP1). This interaction is a critical driver of self-renewal, proliferation, and therapy resistance in glioblastoma stem cells (GSCs). By binding to the 106-126 amino acid domain of PrPC, the peptide competitively inhibits the binding of HOP and other ligands, thereby suppressing downstream signaling pathways that promote tumorigenesis and hypoxia-induced resistance. Preclinical research indicates that HOP230-245 can sensitize GSCs to the alkylating agent temozolomide (TMZ) and inhibit glioblastoma growth in vivo, suggesting its potential as a combination therapy for aggressive brain tumors.
- Other names
- HOP peptideHOP(230-245)
02
Targets
PRNP (Cellular Prion Protein)
Beyond the preview
Go deeper on HOP230-245.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on HOP230-245.