hops

Hops (*Humulus lupulus* L.) strobile extract is a botanical medicine derived from the female flowers of the hop plant. It is primarily used for its sedative and sleep-promoting properties, often as a component of phytotherapeutic products such as Ze 91019 (a fixed combination with valerian root extract developed by Max Zeller Söhne AG). The hops component acts as a melatonin receptor agonist, helping to regulate circadian rhythms and reduce sleep latency. It is indicated for the treatment of nonorganic insomnia and nonorganic disorders of the sleep-wake schedule. Clinical evaluations, including Phase III trials, have demonstrated its efficacy both as a mono-extract and in combination therapies, showing good tolerability without the 'hangover' effects or habituation associated with synthetic sedatives.

Other names

Humulus lupulushops strobile extractHumulus lupulus L. strobile extract