Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
HOTAIR siRNA
- Development stage
- Preclinical
- Lead developer
- MedChemExpress
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intratumoral
01
Overview
HOTAIR siRNA is a research-grade small interfering RNA (siRNA) tool designed to silence the long non-coding RNA (lncRNA) known as HOX transcript antisense RNA (HOTAIR). HOTAIR is frequently overexpressed in various malignancies, where it acts as a scaffold for chromatin-modifying complexes like PRC2 and LSD1, promoting epithelial-to-mesenchymal transition (EMT), metastasis, and drug resistance. By utilizing the RNA interference (RNAi) pathway, HOTAIR siRNA targets HOTAIR transcripts for degradation, thereby inhibiting cancer cell proliferation, migration, and invasion while inducing apoptosis. Preclinical studies have demonstrated that silencing HOTAIR can enhance the chemosensitivity of cancer cells to agents such as cisplatin, doxorubicin, and EGFR-TKIs. Currently, HOTAIR siRNA is utilized primarily as a laboratory reagent for oncology research and is not an approved therapeutic drug.
- Other names
- si-HOTAIRsiRNA-HOTAIRHOX transcript antisense RNA siRNA
02
Targets
HOTAIR
Beyond the preview
Go deeper on HOTAIR siRNA.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on HOTAIR siRNA.