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Houpo Paiqi Heji
- Development stage
- Unknown
- Lead developer
- First Affiliated Hospital of Xi'an Jiaotong University
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Houpo Paiqi Heji is a Traditional Chinese Medicine (TCM) oral liquid formulation primarily used to promote the recovery of gastrointestinal function following surgery. The name "Houpo" refers to *Magnolia officinalis*, a key botanical ingredient known for its prokinetic properties. The formulation is designed to "expel gas" (Paiqi) and alleviate abdominal distension by stimulating intestinal peristalsis and facilitating the first postoperative flatus and defecation. It is frequently integrated into Enhanced Recovery After Surgery (ERAS) protocols to reduce the duration of postoperative ileus and improve patient outcomes after day surgery. The mixture typically contains extracts of *Magnolia officinalis*, *Aurantii Fructus Immaturus*, *Radix et Rhizoma Rhei*, and *Natrii Sulfas*, which collectively act on the enteric nervous system and gastrointestinal hormone receptors to enhance motility.
- Brand names
- Houpo Paiqi Heji
- Other names
- Magnolia Bark Gas-Expelling MixtureHoupo Paiqi MixtureHoupo Paiqi Oral Liquid
02
Targets
mAChR (Muscarinic acetylcholine receptors)MLNR (Human motilin receptor)
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