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house dust mite allergen extract (University of Wisconsin-Madison)
- Development stage
- Phase 3
- Lead developer
- University of Wisconsin–Madison
- Modality
- Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Sublingual
01
Overview
House dust mite SLIT (sublingual immunotherapy) is an investigational allergen-based biologic developed by the University of Wisconsin-Madison for the treatment of allergic rhinitis and mild intermittent asthma. The therapy consists of a *Dermatophagoides farinae* (house dust mite) allergen extract administered sublingually. It works by modulating the immune system's response to dust mite allergens, specifically by increasing allergen-specific IgG4 levels and improving bronchial allergen thresholds, thereby reducing IgE-mediated hypersensitivity. In clinical trials, it has been evaluated in both high-dose (approximately 70 μg Der f 1) and low-dose (approximately 1 μg Der f 1) regimens to determine safety and efficacy in sensitized adults.
- Other names
- house dust mite SLITHDM-SLITDermatophagoides farinae allergen vaccine
02
Targets
TCR (T cell antigen receptor complex)sIgG4 (Allergen-specific immunoglobulin G4)
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