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house dust mite sublingual film
- Development stage
- Unknown
- Lead developer
- Wolwo Biotech
- Modality
- Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Sublingual
01
Overview
House dust mite sublingual film is an allergen immunotherapy (AIT) candidate developed by Zhejiang Wolwo Bio-Pharmaceutical for the treatment of allergic rhinitis, allergic conjunctivitis, and asthma triggered by house dust mites. The product consists of a sublingual film formulation containing standardized extracts of house dust mite allergens (typically *Dermatophagoides farinae*). By delivering the allergen to the sublingual mucosa, the film aims to induce peripheral T-cell tolerance, increase the production of regulatory T cells (Tregs), and shift the immune response from a Th2-biased (allergic) profile to a Th1-biased or regulatory profile. This formulation is intended to provide a more convenient and precise dosing alternative to traditional sublingual drops.
- Other names
- house dust mite sublingual filmHDM sublingual filmhouse dust mite allergen sublingual film
02
Targets
House dust mite-specific B-cell receptorHouse dust mite allergen proteinHouse dust mite allergen peptide-major histocompatibility complex class II (HDM pMHCII)HDM-specific IgE (House dust mite-specific immunoglobulin E)
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