Drug intelligence / Profile preview

HP-6050

Development stage
Unknown
Lead developer
Hisamitsu Pharmaceutical
Modality
Small Molecules
Administration
Transdermal
01

Overview

HP-6050 is a transdermal patch formulation of the typical antipsychotic haloperidol, developed by Hisamitsu Pharmaceutical using its proprietary Transdermal Drug Delivery System (TDDS) technology. It is being developed for the treatment of delirium, psychomotor agitation, and irritability, particularly in elderly patients. Haloperidol acts primarily as a potent antagonist at dopamine D2 receptors in the brain. The transdermal route is intended to provide stable plasma concentrations of the drug over an extended period, potentially reducing the side effects associated with peak plasma levels seen in oral or injectable administration. Furthermore, the patch formulation offers a non-invasive and convenient administration method for patients who may be uncooperative or have difficulty swallowing due to their clinical condition.

Other names
haloperidol transdermal patch
02

Targets

DRD4 (Dopamine D4 Receptor)HTR2A (Serotonin receptor 5-HT2A)HRH1 (Histamine H1 Receptor)ADRA1A (α1A)DRD2 (Dopamine D2 Receptor)SIGMAR1 (Sigma non-opioid intracellular receptor 1)DRD3 (Dopamine receptor D3)

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