HPMA-KCCYSL-DTPA

**HPMA-KCCYSL-DTPA** is an experimental HER2-targeted polymer conjugate developed in academic research. It consists of an N-(2-hydroxypropyl)methacrylamide copolymer scaffold bearing the HER2-binding peptide KCCYSL and diethylenetriaminepentaacetic acid as a metal-chelating group. KCCYSL binds the extracellular domain of human epidermal growth factor receptor 2, enabling preferential association with HER2-expressing tumor cells. The DTPA group permits radiometal complexation; the conjugate has been radiolabeled with indium-111 for SPECT imaging in mouse pancreatic-tumor xenograft studies, including studies evaluating hyaluronidase-mediated stromal depletion to improve tumor penetration. It is a noncommercial, preclinical research-stage imaging and delivery platform rather than an approved medicine. ([sciencedirect.com](https://www.sciencedirect.com/science/article/pii/S0378517313006935))

Other names

HPMA-KCCYSL-DTPA copolymerN-(2-hydroxypropyl)methacrylamide-KCCYSL-DTPA copolymer