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HPV-specific cytokine-induced killer cells
- Development stage
- Preclinical
- Modality
- CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies, Tumor-Infiltrating Lymphocytes (TILs) → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous, Intratumoral, Intraperitoneal, Intracervical
01
Overview
HPV-specific cytokine-induced killer (CIK) cells are a form of adoptive cell therapy in which a patient's immune effector cells are expanded and activated ex vivo using specific cytokines and then redirected to target human papillomavirus (HPV)-infected or HPV-associated tumor cells. These CIK cells possess both T cell and natural killer (NK) cell properties, enabling them to recognize and kill cancerous or virally infected targets in an MHC-unrestricted manner. The mechanism of action involves the direct cytotoxicity against HPV-infected or transformed cervical cancer cells, often mediated by upregulation of activating receptors such as NKG2D on the CIK/NK-like population, as well as secretion of pro-inflammatory cytokines that enhance anti-tumor immunity[1][2]. This approach is being explored primarily for the treatment of cervical cancer and other malignancies associated with persistent high-risk HPV infection.
- Other names
- HPV-specific CIK cellshuman papillomavirus-specific cytokine-induced killer cells
02
Targets
IDO1 (Indoleamine 2,3-dioxygenase 1)NKG2DL (NKG2D ligand family)
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