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HPV-T
- Development stage
- Phase 1
- Lead developer
- BGI
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Tumor-Infiltrating Lymphocytes (TILs) → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
HPV-T is an autologous T-cell therapy developed by BGI for the treatment of HPV-16 positive recurrent or metastatic solid tumors. The therapy utilizes patient-derived T cells that are expanded or engineered to recognize and eliminate cells expressing the HPV-16 E6 and E7 oncoproteins. These proteins are critical for the oncogenic process in HPV-associated malignancies, such as cervical and oropharyngeal cancers. HPV-T is administered intravenously, typically in conjunction with Interleukin-2 (IL-2) to enhance the expansion and persistence of the infused T cells within the patient's body.
- Other names
- HPV-E6/E7-targeting T cellsTumor HPV-E6/E7-Targeting T Cell Suspension
02
Targets
pMHC (Peptide-MHC complex family)HLA-A*02 (Human leukocyte antigen A*02 complexed peptide)
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