Drug intelligence / Profile preview

HPV16 E7 peptide vaccine

Development stage
Phase 2
Lead developer
ISA Pharmaceuticals
Modality
Peptides, Vaccines & Immunotherapeutics
Administration
Subcutaneous, Intramuscular, Intradermal, Intratumoral, Intravenous
01

Overview

HPV16 E7 peptide vaccine is a therapeutic immunotherapy designed to stimulate the host's immune system to recognize and eliminate cells expressing the Human Papillomavirus 16 (HPV16) E7 oncoprotein. The E7 oncoprotein is constitutively expressed in HPV16-associated cancers, such as cervical cancer and vulvar intraepithelial neoplasia, and is essential for maintaining the malignant phenotype of these cells. The vaccine typically consists of synthetic peptides derived from the E7 protein, which are presented to the immune system to induce a cytotoxic T-lymphocyte (CTL) response against HPV16 E7-expressing tumor cells. These vaccines are often administered with adjuvants to enhance the immune response.

Brand names
PepTivator HPV16 E7PepMix HPV 16 (E7)
Other names
HPV16 E7 long peptide vaccineHPV-16 E7 long peptide vaccineHPV 16 E7 long peptide vaccineHPV16 E7 multi-epitopic vaccineHPV-16 E7 multi-epitopic vaccineHPV 16 E7 multi-epitopic vaccineHPV16 E7 peptide-based vaccineHPV-16 E7 peptide-based vaccineHPV 16 E7 peptide-based vaccine
02

Targets

HPV16 E7 (Human papillomavirus 16 E7 protein)

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