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HR070803 + oxaliplatin + 5-fluorouracil + calcium folinate + bevacizumab
- Development stage
- Phase 3
- Lead developer
- Hengrui Therapeutics
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
HR070803 + oxaliplatin + 5-fluorouracil + calcium folinate + bevacizumab is a multi-agent chemotherapeutic regimen, where HR070803 is a novel liposomal formulation of irinotecan. This combination is under investigation primarily for first-line treatment of unresectable, locally advanced, or metastatic pancreatic ductal adenocarcinoma (PDAC)[1][3]. HR070803 delivers irinotecan in a liposomal form for prolonged circulation and slow release, improving delivery and tolerability[1][3]. Oxaliplatin is a platinum-based cytotoxic agent that forms DNA crosslinks, leading to apoptosis. 5-fluorouracil (5-FU) is a pyrimidine analog that inhibits thymidylate synthase, blocking DNA synthesis. Calcium folinate (leucovorin) enhances the cytotoxicity of 5-FU. Bevacizumab is a monoclonal antibody that targets vascular endothelial growth factor A (VEGF-A), inhibiting tumor angiogenesis[2][6].
- Other names
- irinotecan liposome + oxaliplatin + 5-fluorouracil + leucovorin + bevacizumab
02
Targets
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