Drug intelligence / Profile preview

HR1405-01

Development stage: Unknown
Lead developer: Nanjing Heron Pharmaceutical Science & Technology
Modality: Small Molecules
Administration: Intravenous

Overview

HR1405-01 is a novel intravenous non-steroidal anti-inflammatory drug (NSAID) developed as the bioactive metabolite of loxoprofen. It was designed to overcome the solubility and bioavailability limitations of existing intravenous NSAIDs. Preclinical studies demonstrate that HR1405-01 has significantly stronger analgesic and anti-inflammatory activities compared to parecoxib sodium and ibuprofen injections, with more than tenfold greater potency in some pain models. Its high solubility allows for formulation without cosolvents, reducing side effects and improving safety. The drug exhibits a faster time to peak concentration (Tmax) and requires lower effective doses than oral loxoprofen. Developed by Nanjing Heron Pharmaceutical Science & Technology Co., Ltd., it is currently in phase 2 clinical trials for postoperative pain management[1][2][3][4][7].

Other names: Loxoprofenol-SRS tromethamine

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

Beyond the preview

Go deeper on HR1405-01.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on HR1405-01.

Explore the full profile