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HR1405-01
- Development stage
- Phase 3
- Lead developer
- Nanjing Heron Pharmaceutical Science & Technology
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
HR1405-01 is a novel intravenous non-steroidal anti-inflammatory drug (NSAID) developed as the bioactive metabolite of loxoprofen. It was designed to overcome the solubility and bioavailability limitations of existing intravenous NSAIDs. Preclinical studies demonstrate that HR1405-01 has significantly stronger analgesic and anti-inflammatory activities compared to parecoxib sodium and ibuprofen injections, with more than tenfold greater potency in some pain models. Its high solubility allows for formulation without cosolvents, reducing side effects and improving safety. The drug exhibits a faster time to peak concentration (Tmax) and requires lower effective doses than oral loxoprofen. Developed by Nanjing Heron Pharmaceutical Science & Technology Co., Ltd., it is currently in phase 2 clinical trials for postoperative pain management[1][2][3][4][7].
- Other names
- Loxoprofenol-SRS tromethamine
02
Targets
PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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