Drug intelligence / Profile preview

HRO350

Development stage
Phase 2
Lead developer
Arctic Bioscience
Modality
Small Molecules, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Oral
01

Overview

HRO350 is a first-in-class, orally administered investigational drug developed for the treatment of mild-to-moderate psoriasis. It consists of a complex polar lipid matrix extracted from immature herring roe (Clupea harengus), with phospholipids rich in marine polyunsaturated fatty acids as its active pharmaceutical ingredient (API). The main component, known as PEHeRo (phospholipid esters from herring roe oil), is naturally present in the human diet. While the precise mechanism of action is not fully elucidated, preclinical and cellular studies indicate that HRO350 may exert immunomodulatory and anti-inflammatory effects relevant to psoriasis pathogenesis. The drug is being evaluated in phase 2b clinical trials across multiple European countries to determine its efficacy, safety profile, and optimal dosing for patients with mild-to-moderate psoriasis[1][2][3][4][5][6][7].

Brand names
psorax35psorax-35psorax 35
Other names
PEHeRoPhospholipid Esters from Herring Roe
02

Targets

LTB4R (Leukotriene B4 Receptor 1)CMKLR1 (Chemokine-like receptor 1)FFAR4 (Free fatty acid receptor 4)GPR32 (G protein-coupled receptor 32)IL-23 (Interleukin-23)

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