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Drug intelligence / Profile preview
HRS-4642 + cetuximab
- Development stage
- Phase 2
- Lead developer
- Hengrui Therapeutics
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules, Liposomes → Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
**HRS-4642 + cetuximab** is a combination investigational therapy comprised of HRS-4642, a selective long-acting KRAS G12D inhibitor formulated as a liposomal injection, and cetuximab, an epidermal growth factor receptor (EGFR) monoclonal antibody. HRS-4642 inhibits mutant KRAS G12D, suppressing downstream MEK/ERK phosphorylation to block tumor cell proliferation. Cetuximab antagonizes EGFR-mediated signaling, counteracting adaptive feedback resistance commonly triggered by KRAS inhibition. The combination aims to improve efficacy in advanced solid tumors, especially pancreatic ductal adenocarcinoma (PDAC) with KRAS G12D mutations that are refractory to standard therapies.[1][3][5]
- Other names
- HRS-4642 + cetuximabHRS-4642 plus cetuximabHRS4642 plus cetuximabHRS 4642 plus cetuximabErbitux (for cetuximab)
02
Targets
EGFR (Epidermal growth factor receptor)KRASG12D (Kirsten rat sarcoma viral oncogene homolog (KRAS) G12D mutant)
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