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HRS-7058 + SHR-1316 + platinum-containing doublet chemotherapy

Development stage
Preclinical
Lead developer
Hengrui Therapeutics
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous, Oral
01

Overview

HRS-7058 + SHR-1316 + platinum-containing doublet chemotherapy is a combination regimen under investigation for cancer treatment, particularly non-small cell lung cancer (NSCLC). HRS-7058 and SHR-1316 are investigational agents; while specific mechanisms for these two drugs are not detailed in the provided sources, they are likely targeted therapies or immunotherapies based on naming conventions. Platinum-containing doublet chemotherapy refers to a standard regimen that combines a platinum agent (such as cisplatin or carboplatin) with a third-generation cytotoxic drug (such as docetaxel, paclitaxel, vinorelbine, gemcitabine, irinotecan, pemetrexed, or S-1). This combination exploits synergistic effects between agents with different mechanisms of action to improve response rates in cancers like NSCLC[1][2][5]. The addition of novel agents such as immune checkpoint inhibitors to this backbone is an emerging strategy in oncology[3][4].

Other names
platinum-containing doublet chemotherapyplatinum doublet therapy
02

Targets

CD274 (Programmed cell death protein 1 ligand 1)DNA

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