HRS-8427 + furosemide

**HRS-8427 + furosemide** is a combination of two drugs: HRS-8427, a novel investigational small molecule anti-infective under development primarily for infectious and respiratory diseases[1][3], and **furosemide**, a well-established loop diuretic commonly used for edema and hypertension[6]. The combination has been tested in clinical studies to assess pharmacokinetic interactions and safety, primarily in healthy subjects; HRS-8427 has known activity against complicated urinary tract infections, acute pyelonephritis, hospital-acquired bacterial pneumonia, and lung infections[1][3][5][7]. Furosemide acts by inhibiting the sodium-potassium-chloride cotransporter NKCC2, promoting natriuresis and diuresis[6]. The mechanism of action for HRS-8427 has not been publicly disclosed; trials evaluating this combination focus on transporter-mediated (OAT1 for furosemide) drug interactions and safety[1][9]. The combination is administered intravenously in clinical studies[1][3][8][10].

Other names

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