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HS-10535
- Development stage
- Phase 1
- Lead developer
- Merck
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
HS-10535 is an investigational preclinical oral small molecule glucagon-like peptide 1 receptor (GLP-1R) agonist developed by Hansoh Pharma. It is designed for the treatment of obesity and type 2 diabetes and may have broader applications in cardiometabolic disorders. The drug acts as a GLP-1 receptor agonist to promote weight loss and improve metabolic parameters. In December 2024, Merck (MSD outside the US/Canada) obtained exclusive global rights to develop, manufacture, and commercialize HS-10535 outside China; Hansoh retains certain commercialization rights within China[1][4][5][6]. Preclinical data suggest potent GLP-1R activation with significant weight reduction in animal models[6]. The compound is structurally distinct from other oral GLP-1 agents such as orforglipron[6].
- Other names
- HS-10535HS10535HS 10535MK 4082MK4082MK-4082
02
Targets
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