HS-20116

HS-20116 is a **chitosan-based biomaterial** intended for **intra-articular injection** for the treatment of **knee osteoarthritis**. Developed as a novel therapeutic approach, it is being investigated as an **antirheumatic** intervention to alleviate pain and improve joint function in patients suffering from symptomatic knee osteoarthritis. HS-20116 utilizes the properties of chitosan, a biopolymer derived from chitin, which is hypothesized to aid in joint lubrication, act as a scaffold for tissue repair, and potentially modify the osteoarthritic environment, although its precise mechanism of action remains undefined. The drug is administered directly into the knee joint and is under late-stage clinical development, with completed Phase III trials in China as of August 2025.