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HS-20118 is an investigational small molecule drug being developed primarily for the treatment of moderate to severe plaque psoriasis. It is administered orally and is currently in Phase 1 clinical trials, where its safety, tolerability, immunogenicity, pharmacokinetics (PK), and pharmacodynamics (PD) are being evaluated in both healthy volunteers and patients with plaque psoriasis. The precise mechanism of action for HS-20118 has not been disclosed or defined publicly as of June 2025. The drug is a new molecular entity classified under antipsoriatics. Development and sponsorship are led by Jiangsu Hansoh Pharmaceutical Co., Ltd., also known as Hansoh Pharma[1][4][5][6][8].
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