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HST-2011
- Development stage
- Preclinical
- Lead developer
- HotSpot Therapeutics
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
HST-2011 is a first-in-class small molecule allosteric inhibitor of Interferon Regulatory Factor 5 (IRF5), developed by HotSpot Therapeutics using its proprietary Smart Allostery™ platform. IRF5 is a transcription factor that serves as a master regulator of the innate immune response, controlling the expression of type I interferons and other pro-inflammatory cytokines. Historically, IRF5 was considered undruggable due to the lack of a traditional active site; however, HST-2011 targets a naturally occurring allosteric "hotspot" to potently and selectively inhibit its activity. The drug is currently in IND-enabling studies for the treatment of various autoimmune and inflammatory conditions, including systemic lupus erythematosus (SLE), Sjögren's syndrome, and systemic sclerosis.
- Other names
- HST-2011HST2011HST 2011
02
Targets
IRF5 (Interferon regulatory factor 5)
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