Drug intelligence / Profile preview

HSV 2 Formulation 2

Development stage
Discontinued
Lead developer
Parent
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

**HSV 2 Formulation 2** was a trial-specific, intramuscular investigational therapeutic HSV-2 vaccine formulation evaluated by Sanofi in adults with recurrent genital herpes. It was one of six masked formulation labels used in the terminated HSV15 study, which assessed safety and effects on genital HSV DNA shedding and recurrence after a two-dose schedule. Public trial materials do not identify the precise antigen composition corresponding specifically to Formulation 2; the broader program evaluated formulations involving the replication-defective HSV529 vaccine and the recombinant-protein vaccine G103, with GLA-SE adjuvant used in program formulations. ([ctv.veeva.com](https://ctv.veeva.com/study/safety-and-efficacy-of-4-investigational-hsv-2-vaccines-in-adults-with-recurrent-genital-herpes-caus))

Other names
HSV formulation 2
02

Targets

TLR4 (Toll-like receptor 4)

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