HSV1 UL53-RTK-UL54

HSV1 UL53-RTK-UL54 is an engineered, replication-defective herpes simplex virus type 1 (HSV-1) construct used primarily as a research tool in the study of oncolytic viral therapy and glioblastoma multiforme (GBM). The virus is characterized by a deletion of the UL54 gene, which encodes the essential immediate-early protein ICP27, rendering it unable to complete a lytic replication cycle in non-complementing cells. It also contains a green fluorescent protein (GFP) reporter gene, allowing for the visualization of viral entry and early gene expression. Researchers at the University of British Columbia have utilized this construct to investigate mechanisms of glioma cell resistance to HSV-1 infection, specifically identifying that low expression of the tumor suppressor MEOX2 contributes to resistance against viral entry in stem-like glioma cell lines.

Other names

ICP27-deleted HSV-1 expressing GFPICP-27-deleted HSV-1 expressing GFPICP 27-deleted HSV-1 expressing GFPUL54-deleted HSV-1UL-54-deleted HSV-1UL 54-deleted HSV-1