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HU1084-DXD
- Development stage
- Preclinical
- Lead developer
- Central Institute for Experimental Animals
- Modality
- Small Molecules, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
HU1084-DXD is an **antibody-drug conjugate (ADC)** composed of a humanized anti-tissue factor monoclonal antibody (clone 1084, referred to as hu1084) conjugated to **deruxtecan (DXd)**, a topoisomerase I inhibitor payload, via a cleavable linker. The antibody targets tissue factor (TF), which is highly expressed in several cancers, including pancreatic cancer. Upon binding to TF-positive tumor cells, HU1084-DXD is internalized and releases DXd intracellularly, leading to DNA damage and cell death. Preclinical studies demonstrated that HU1084-DXD exhibits significant antitumor activity in cell line-derived and patient-derived xenograft models of pancreatic cancer.
02
Targets
TOP1 (DNA Topoisomerase I)F3 (Tissue factor)
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