Huaiqihuang Granule placebo

Huaiqihuang Granule placebo is a pharmacologically inert control substance used in clinical research to evaluate the efficacy and safety of Huaiqihuang Granule, a Traditional Chinese Medicine (TCM). In the specific context of the Phase 4 trial (NCT03554824) led by Jianhua Zhou, the placebo is used as a comparator in children with primary nephrotic syndrome. The active Huaiqihuang Granule formulation consists of *Trametes robiniophila murr* (Huaier), *Fructus Lycii* (wolfberry), and *Polygonatum sibiricum*. The placebo is designed to be indistinguishable from the active granules in appearance, taste, and odor but lacks the medicinal extracts. It is typically administered as an adjuvant to glucocorticoid therapy (such as prednisone) to determine if the active TCM provides additional benefits in regulating immune function and reducing relapse rates in pediatric patients.

Other names

Huai Qi Huang placeboHQH placebo