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huanghuahao pollen drops
- Development stage
- Unknown
- Lead developer
- Wolwo Biotech
- Modality
- Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Sublingual
01
Overview
Huanghuahao pollen drops is a sublingual allergen immunotherapy (SLIT) developed by Zhejiang Wolwo Bio-Pharmaceutical for the treatment of seasonal allergic rhinitis caused by *Artemisia annua* (sweet wormwood) pollen. The product consists of a standardized extract of Huanghuahao pollen. By administering increasing doses of the allergen sublingually, the treatment aims to induce immunological tolerance, shifting the immune response from a Th2-mediated allergic reaction toward a Th1 and regulatory T-cell (Treg) response, thereby reducing symptoms and the need for rescue medication during pollen season. It was approved by the NMPA in China in 2021 for use in both adults and children.
- Brand names
- Changshi畅适
- Other names
- Artemisia annua pollen dropsHuanghuahao pollen sublingual drops黄花蒿花粉滴剂
02
Targets
IgE (Immunoglobulin E)BCR (Immunoglobulin G B Cell Receptor)Artemisia annua allergen-specific T-cell receptor
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