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Huangjing Pills
- Development stage
- Unknown
- Lead developer
- Beijing Tong Ren Tang
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Huangjing Pills (also known as Huangjing Wan or Jiuzhuan Huangjing Pills) is a traditional Chinese medicine (TCM) formula composed of Polygonati Rhizoma (Huangjing) and Angelicae Sinensis Radix (Danggui). It is traditionally used to tonify qi, nourish blood, and strengthen the spleen, kidneys, and lungs. It is approved in China for the treatment of qi and blood deficiency, physical weakness, fatigue, and weakness of the waist and legs. Modern pharmacological research has also investigated its potential therapeutic effects in metabolic dysfunction-associated fatty liver disease (MAFLD), ischemic stroke, and Alzheimer's disease, primarily through mechanisms involving the protection of mitochondrial function, reduction of oxidative stress, and regulation of lipid metabolism.
- Other names
- Huangjing WanJiuzhuan Huangjing PillsJiuzhuan Huangjing Wan九转黄精丸黄精丸
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)HIF1A (Hypoxia-inducible factor 1-alpha)JNK (Mitogen-activated protein kinase kinase kinase family)MAPK14 (p38 mitogen-activated protein kinase alpha)RELA (Nuclear Factor Kappa B Subunit p65)RXRA (Retinoid X receptor alpha)AMY (Pancreatic alpha-amylase)Sucrase-Isomaltase
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