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Drug intelligence / Profile preview
Huangjing Wan (960864)
- Development stage
- Preclinical
- Administration
- Oral
01
Overview
Huangjing Wan (HJW) is a classical Traditional Chinese Medicine (TCM) herbal formula recorded in the *Taiping Huimin Heji Jufang* (He Ji Ju Fang). It is traditionally formulated with three main ingredients: Huangjing (*Polygonatum cyrtonema*), Danggui (*Angelica sinensis*), and Heidou (black beans), prepared with honey. Huangjing Wan is primarily studied for its potential neuroprotective and therapeutic effects in ischemic stroke. Network pharmacology studies suggest that HJW contains multiple active ingredients (such as baicalein, beta-sitosterol, diosgenin, and stigmasterol) that target various biological pathways, including the Hepatitis B virus pathway, lipid and atherosclerosis pathway, and cell apoptosis pathway, to mitigate cerebral ischemia-reperfusion injury.
- Other names
- Huangjing-WanHuangjingwan
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)BCL-2 (BCL-2 family)CHRM3 (M3)PDE3A (Phosphodiesterase 3A)PR (Progesterone receptor)PGHS-1 (Prostaglandin G/H Synthase 1)RELA (Nuclear Factor Kappa B Subunit p65)SCN5A (Sodium channel protein type 5 subunit alpha)SERT (Sodium-dependent serotonin transporter)TP53 (Cellular Tumor Antigen p53 R175H)VEGFA (Vascular endothelial growth factor A)
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