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Huanglian Ejiao
- Development stage
- Phase 2
- Lead developer
- Dong-E-E-Jiao
- Modality
- Small Molecules, Peptides
- Administration
- Oral
01
Overview
Huanglian Ejiao is a Traditional Chinese Medicine (TCM) formulation, primarily developed and marketed by Shandong Dong'e Ejiao Co., Ltd., based on the classic 'Huanglian Ejiao Tang' decoction first described in the *Shanghan Lun*. It is indicated for the treatment of chronic insomnia, anxiety, and irritability, conditions often associated in TCM with 'yin deficiency and fire hyperactivity' or 'heart-kidney disharmony.' The formula is a combination of *Coptis chinensis* (Huanglian), *Asini Corii Colla* (Ejiao/donkey-hide gelatin), *Scutellaria baicalensis*, *Paeonia lactiflora*, and egg yolk. Pharmacologically, Huanglian Ejiao is thought to exert its sedative and anxiolytic effects by modulating the GABAergic system (specifically GABA-A receptors) and the serotonergic system, while also reducing neuroinflammation through the inhibition of pro-inflammatory cytokines like IL-6 and TNF-alpha. It is widely available in China in modern dosage forms such as granules and capsules.
- Brand names
- Dong'e Ejiao
- Other names
- Huanglian Ejiao TangHuanglian Ejiao Decoction
02
Targets
5-HT (Serotonin receptors)GABRA1 (Gamma-aminobutyric acid type A receptor alpha 1 subunit)
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