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huangqi gegen decoction granules
- Development stage
- Unknown
- Lead developer
- Central Hospital of Shanghai Putuo District
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Huangqi Gegen Decoction Granules is a Traditional Chinese Medicine (TCM) formulation composed of *Astragalus membranaceus* (Huangqi) and *Pueraria lobata* (Gegen). Developed by Putuo Hospital and the Shanghai University of Traditional Chinese Medicine, this decoction is primarily indicated for the treatment of endothelial dysfunction in patients with type 2 diabetes mellitus (T2DM) who are at high risk for atherosclerotic cardiovascular disease (ASCVD). The formulation is specifically tailored for patients exhibiting Qi-Yin deficiency syndrome. Clinical evaluation focuses on its ability to improve flow-mediated dilation (FMD) and regulate blood glucose levels alongside conventional treatments. The granules are manufactured by Jiangyin Tianjiang Pharmaceutical.
- Other names
- Huangqi Gegen Decoction GranulesHuangqi Gegen DecoctionHQGG
02
Targets
HMGB1 (High mobility group protein B1)KEAP1 (Kelch-like ECH-associated protein 1)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)NFKB1 (NF-κB1)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)
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