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huangqi granules
- Development stage
- Unknown
- Lead developer
- Nanjing Tongrentang
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Huangqi granules is a traditional Chinese medicine (TCM) preparation formulated from the extract of Radix Astragali (the dried root of *Astragalus membranaceus* or *Astragalus mongholicus*). It is widely used in China to tonify Qi, strengthen superficial resistance, and promote diuresis to reduce edema. Pharmacologically, Huangqi granules exhibit immunomodulatory, anti-inflammatory, antioxidant, and antiviral properties, primarily attributed to active components such as astragalosides, flavonoids (e.g., calycosin, formononetin), and polysaccharides. The preparation is approved in China for the treatment of Qi deficiency and the prevention of recurrent respiratory tract infections. It has also been investigated as a supportive or therapeutic option in pediatric patients with COVID-19, asthma, viral myocarditis, and nephrotic syndrome.
- Other names
- Astragali Radix granulesAstragalus granulesHuangqi granuleRadix Astragali granules黄芪颗粒
02
Targets
CHRM3 (M3)NOS2 (Nitric Oxide Synthase 2)ESR1 (ERα)HSP90AA1 (Heat shock protein HSP90-alpha)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)MAPK3 (Mitogen-activated protein kinase 1)RXRA (Retinoid X receptor alpha)
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