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huangqi sini decoction

Development stage
Preclinical
Administration
Oral
01

Overview

Huangqi Sini Decoction is a traditional Chinese medicine (TCM) herbal formula composed primarily of Huangqi (Radix Astragali, also known as astragalus root) and other herbs. It is used in TCM to treat conditions associated with "yang deficiency" and poor circulation, such as cold extremities and chronic fatigue. The formula typically includes astragalus root for its immunomodulatory, anti-inflammatory, antioxidant, and cardioprotective effects[3][6]. The mechanism of action is believed to involve modulation of immune function, reduction of inflammation and oxidative stress, improvement in microcirculation, and enhancement of energy metabolism. Modern pharmacological studies attribute these effects mainly to the saponins (e.g., astragalosides), flavonoids (e.g., calycosin), polysaccharides from astragalus root[3][6], along with synergistic actions from the other component herbs.

Other names
黄芪四逆汤Huangqi Sini Tang
02

Targets

PPARD (Peroxisome proliferator–activated receptor delta)PAI-1 (Plasminogen activator inhibitor type 1)MMP9 (Matrix metalloproteinase-9)CDK1 (Cyclin-dependent kinase 1)HIF1A (Hypoxia-inducible factor 1-alpha)TP53 (Cellular Tumor Antigen p53 R175H)

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