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huangqin zhengqi
- Development stage
- Phase 2
- Lead developer
- Guangzhou University of Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Huangqin Zhengqi is a Traditional Chinese Medicine (TCM) formulation developed by the Guangzhou University of Chinese Medicine, specifically indicated for the treatment of infectious diarrhea. The formula is primarily based on *Scutellaria baicalensis* (Huangqin), which is recognized for its potent anti-inflammatory, antimicrobial, and antipyretic properties. Clinically, it is used to address 'damp-heat' syndrome, a TCM classification that correlates with acute enteritis and viral or bacterial gastroenteritis. The drug's mechanism of action involves the inhibition of pro-inflammatory cytokines, protection of the intestinal mucosal barrier, and direct inhibitory effects against various enteric pathogens. It is commonly administered as an oral liquid in hospital settings in China.
- Brand names
- Huangqin Zhengqi Oral Liquid
- Other names
- Huangqin ZhengqiHuangqin Zhengqi formula
02
Targets
NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)SERT (Sodium-dependent serotonin transporter)STAT3 (Signal Transducer and Activator of Transcription 3)IL-6 (Interleukin 6)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)TNFA (Tumor necrosis factor alpha (soluble))
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