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Huatan Dingji Formula

Development stage: Unknown
Lead developer: Longhua Hospital Shanghai University of Traditional Chinese Medicine
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

Huatan Dingji Formula (also known as Huatan Dingji Decoction or HTDJ) is a traditional Chinese medicine (TCM) herbal formula developed at Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. It is designed for the treatment of atrial fibrillation (AF), specifically targeting the TCM syndrome pattern of qi deficiency and phlegm opacities (palpitation of qi deficiency-caused phlegm stagnation). The formula is composed of multiple herbal ingredients, including pinellia ginger, tangerine peel, astragalus root, atractylode rhizome, Poria, Coptis chinensis, cinnamon, keel, oyster, Radix ophiopogonis, Chinese date, Epimedium, and sophora flavescens. It is evaluated in clinical trials in combination with western basic therapy to reduce the frequency of palpitation, cumulative attack time, and improve clinical symptoms and quality of life in patients with paroxysmal or persistent atrial fibrillation.

Other names: Huatan Dingji Decoction化痰定悸方化痰定悸汤

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