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Huatan Huoxue Recipe is a traditional Chinese medicine (TCM) formula used primarily for the treatment of conditions characterized by "phlegm" and "blood stasis" syndromes, according to TCM theory. It is most commonly applied in the management of vertigo, coronary heart disease with phlegm–blood stasis syndrome, and other disorders involving inflammation or abnormal lipid metabolism. The formula typically contains herbs that are believed to resolve phlegm (huatan), promote blood circulation (huoxue), and address underlying imbalances in the body. Clinical studies suggest it can improve symptoms such as dizziness, anxiety, depression, and autonomic dysfunction in patients with vertigo of unknown origin[3]. Mechanistically, it may exert anti-inflammatory effects by downregulating inflammatory mediators like IL-6 and TNF-α[2], modulate lipid profiles by reducing LDL-C levels[1], protect mitochondrial structure in liver cells[4], and inhibit cancer stem cell proliferation when combined with other herbal components[5]. The precise molecular targets remain incompletely defined but likely involve modulation of inflammatory pathways such as PI3K/AKT/NF-κB signaling.
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