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huatan jiangzhuo decoction
- Development stage
- Preclinical
- Lead developer
- Guangzhou University of Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Huatan Jiangzhuo decoction (HJD) is a traditional Chinese medicine (TCM) formula composed of six herbal ingredients: *Atractylodis Rhizoma*, *Atractylodis Macrocephalae Rhizoma*, *Citri Reticulatae Pericarpium*, *Pinelliae Rhizoma*, *Poria*, and *Alisma Rhizoma*. It is traditionally used to treat lipid metabolism-related disorders, including hyperlipidemia, angina pectoris, and fatty diabetes. Research indicates that HJD exerts its lipid-lowering effects by modulating the expression of key genes involved in cholesterol and fatty acid metabolism, such as cholesterol 7-alpha-hydroxylase (CYP7A1), liver X receptor alpha (LXRα), peroxisome proliferator-activated receptor gamma (PPARγ), and sterol regulatory element-binding protein 1c (SREBP1c). It appears to act through the PPAR, AMPK, and insulin signaling pathways to reduce total cholesterol and triglyceride levels and alleviate hepatic lipid accumulation.
- Other names
- Huatan Jiangzhuo decoction
02
Targets
PPARG (Peroxisome proliferator-activated receptor gamma)SREBP-1 / SREBF1 (SREBP-1)NR1H3 (Liver X receptor beta)CYP7A1 (Cholesterol 7alpha-hydroxylase)
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