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Huatuo Zaizao
- Development stage
- Phase 4
- Lead developer
- Guangzhou Baiyunshan Qixing Pharmaceutical
- Administration
- Oral
01
Overview
Huatuo Zaizao is a Traditional Chinese Medicine (TCM) herbal formula primarily used for the treatment and rehabilitation of ischemic stroke. Developed and manufactured by Guangzhou Baiyunshan Zhongyi Pharmaceutical, it is composed of multiple botanical ingredients including *Ligusticum chuanxiong*, *Evodia rutaecarpa*, and *Panax ginseng*. The formula is designed to promote blood circulation, resolve blood stasis, and improve neurological recovery. Clinical studies, including Phase 4 trials, have evaluated its efficacy in improving motor function and neurological deficits in patients during both the acute and recovery stages of stroke. Its pharmacological mechanism is thought to involve neuroprotective effects, anti-inflammatory activity, and the modulation of cerebral blood flow.
- Brand names
- Huatuo Zaizao PillHuatuo Zaizao Wan
- Other names
- hua tuo zai zao wan
02
Targets
CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)Protein kinase A–cAMP response element-binding protein–brain-derived neurotrophic factor signaling axis (PKA–CREB–BDNF axis)RYR2 (Ryanodine receptor 2)
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