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Huayu Qutan Recipe
- Development stage
- Preclinical
- Lead developer
- Liaoning University of Traditional Chinese Medicine
- Administration
- Oral
01
Overview
Huayu Qutan Recipe is a traditional Chinese medicine (TCM) compound prescription comprising nine to ten herbal ingredients, most frequently used for the management of cardiovascular and metabolic diseases including atherosclerosis and heart failure. Its documented mechanism of action is multi-target and multi-pathway, involving the promotion of lipophagy, reduction of foam cell formation, cholesterol efflux, and cardioprotection through modulation of signaling axes such as mTORC1/TFEB/ABCA1-SCARB1, PI3K/Akt/Bad, and SREBP-2. Key ingredients include Codonopsis pilosula, Astragalus membranaceus, Gynostemma pentaphyllum, Salvia miltiorrhiza, Poria cocos, Pinellia ternata, Acorus tatarinowii, Ligusticum chuanxiong, and Curcuma wenyujin. Pharmacological studies demonstrate effects on STAT3, MAPK3, AKT1, JUN, MAPK1, TP53, TNF, HSP90AA1, p65, MAPK8, MAPK14, IL6, EGFR, EDN1, FOS, PTGS2, ESR1, AR, PTGS1, NOS2, SCN5A, PRSS1, GSK3B, PPARG, CCNA2, ESR2, ADRB2, DPP4, F10, and RXRA, among others, with downstream impact on mitochondrial function, oxidative stress, lipid metabolism, and inflammation. The formula is administered orally and is used predominantly in TCM clinical practice in China for heart failure, atherosclerosis, acute myocardial infarction, and dyslipidemia[2][3][1].
- Brand names
- Huayu Qutan Recipe
- Other names
- Huayu Qutan FormulaHYQT decoction
02
Targets
ABCA1 (ATP-binding cassette transporter A1)BAX (Apoptosis regulator BAX)IL-6 (Interleukin 6)MAPK3 (Mitogen-activated protein kinase 1)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)SCARB1 (Scavenger receptor class B member 1)SREBP-2 / SREBF2 (SREBP-2)STAT3 (Signal Transducer and Activator of Transcription 3)TFEB (Transcription factor EB)Mechanistic target of rapamycin complex 1BAD (Bcl-2-associated agonist of cell death)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TNFA (Tumor necrosis factor alpha (soluble))
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