Drug intelligence / Profile preview

Huayu Sanjie Guanchangye

Development stage
Preclinical
Lead developer
Changhai Hospital
Administration
Rectal
01

Overview

Huayu Sanjie Guanchangye is a Traditional Chinese Medicine (TCM) liquid formulation developed by Changhai Hospital (Affiliated to the Second Military Medical University) for the treatment of endometriosis. The name translates to "Blood-Stasis-Resolving and Nodule-Dissipating Enema Liquid." It is administered rectally as an enema to provide localized treatment for pelvic endometriotic lesions. In TCM theory, endometriosis is often characterized by blood stasis and the formation of pelvic masses (nodules); this formulation aims to promote blood circulation, resolve stasis, and shrink endometriotic lesions. Clinical studies, such as the prospective randomized case-control study ChiCTR-IPC-16008214, have investigated its therapeutic effect in reducing pain and preventing the progression of endometriosis.

Other names
Huayu Sanjie EnemaHuayu Sanjie Rectal Solution
02

Targets

IL-6 (Interleukin 6)TRPV1 (Transient receptor potential cation channel subfamily V member 1)TNFA (Tumor necrosis factor alpha (soluble))PAI-1 (Plasminogen activator inhibitor type 1)CXCL2 (C-X-C motif chemokine ligand 2)TGFB (GARP–latent transforming growth factor beta 1 complex)mPGES-2 (Microsomal prostaglandin E synthase-2)

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