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Huazhuo Tongmai Decoction

Development stage: Preclinical
Administration: Oral

Overview

Huazhuo Tongmai Decoction is a traditional Chinese medicine (TCM) herbal formula used primarily for the treatment and prevention of atherosclerosis and related cardiovascular diseases. It is composed of multiple medicinal herbs, following TCM principles aimed at "removing blood stasis," promoting blood circulation, and unblocking the meridians. Preclinical studies suggest that this decoction exerts anti-atherosclerotic effects by modulating lipid metabolism, reducing inflammation, and improving vascular function[2]. The precise mechanism involves multi-target actions typical of TCM formulas; however, specific molecular targets are not fully elucidated in current literature.

Brand names: Huazhuo Tongmai Decoction
Other names: Huazhuotongmai Decoction

Targets

AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)CD36 (CD36 antigen)PPARG (Peroxisome proliferator-activated receptor gamma)VEGFA (Vascular endothelial growth factor A)

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