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Huazhuo Tongmaifang granules
- Development stage
- Preclinical
- Lead developer
- Xiyuan Hospital
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Huazhuo Tongmaifang granules (also known as Huazhuo Tongmai Decoction) is an investigational traditional Chinese medicine (TCM) herbal formulation developed by Xiyuan Hospital of the Chinese Academy of Traditional Chinese Medicine. It is primarily indicated for the treatment of primary hyperlipidemia and carotid atherosclerosis, particularly in patients presenting with the phlegm-turbidity obstruction syndrome (痰浊阻遏证). The formulation is designed to lower lipid levels and exert anti-atherosclerotic effects. Mechanistically, Huazhuo Tongmaifang granules have been shown to promote cholesterol reverse transport in foam cells, upregulate the expression of ATP-binding cassette transporter A1 (ABCA1) and caveolin-1 (Cav-1), and regulate lipid autophagy to inhibit macrophage foam cell formation and reduce arterial plaque progression.
- Other names
- Huazhuo Tongmai DecoctionHuazhuo Tongmaifang Granule化浊通脉方化浊通脉方颗粒
02
Targets
SCARB1 (Scavenger receptor class B member 1)PPARG (Peroxisome proliferator-activated receptor gamma)ABCA1 (ATP-binding cassette transporter A1)CAV1 (Caveolin-1)
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