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HuB14-VA-PL2202
- Development stage
- Preclinical
- Lead developer
- ADC Therapeutics
- Modality
- Small Molecules, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
HuB14-VA-PL2202 is a novel antibody-drug conjugate (ADC) developed by ADC Therapeutics. It targets the alanine, serine, cysteine transporter 2 (ASCT2), which is over-expressed in both solid and hematological cancers. The drug combines a monoclonal antibody specific for ASCT2 with a cytotoxic payload that inhibits DNA topoisomerase I (TOP1). Preclinical studies have demonstrated potent and specific anti-tumor activity in ASCT2-positive cancer cell lines, with efficacy observed both in vitro and in vivo. The compound has shown good tolerability in cynomolgus monkeys during preclinical testing[1][3][5][6][8].
02
Targets
SLC1A5 (Alanine/serine/cysteine transporter 2)
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