Drug intelligence / Profile preview

Hubei Univ. of Medicine EGFR compound 10a

Development stage
Unknown
Lead developer
Hubei Medical College
01

Overview

Hubei Univ. of Medicine EGFR compound 10a: sourced facts only. name: "It is worth mentioning that the coumarin-furo[2,3-d]pyrimidone combination 10a showed excellent inhibition of the EGFR enzymatic activity with IC50 = 1.53 μM and 90% inhibition at 10 μM concentration." [PMID:38784474]; target: "It is worth mentioning that the coumarin-furo[2,3-d]pyrimidone combination 10a showed excellent inhibition of the EGFR enzymatic activity with IC50 = 1.53 μM and 90% inhibition at 10 μM concentration." [PMID:38784474]; developer: "School of Pharmacy, Hubei University of Medicine Shiyan 442000 Hubei China [email protected]." [PMID:38784474]; stage: "The coumarin-furo[2,3-d]pyrimidone combination 10a exhibited significant inhibitory activity against HepG2 cells with IC50 = 7.72 ± 1.56 μM, which is better than those of gefitinib and sorafenib." [PMID:38784474]

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