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huCD33-BsAb
- Development stage
- Discontinued
- Lead developer
- Y-mAbs Therapeutics
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Subcutaneous, Parenteral
01
Overview
**huCD33-BsAb** is a humanized bispecific monoclonal antibody developed by Y-mAbs Therapeutics (a subsidiary of SERB) originating from Memorial Sloan-Kettering Cancer Center. It targets **CD33** on myeloid leukemia cells and **CD3** on T cells, redirecting T-cell cytotoxicity to induce **antibody-dependent cell cytotoxicity (ADCC)** while inhibiting CD33 and stimulating T lymphocytes. Primarily investigated for **acute myeloid leukemia (AML)** in adults, adolescents, and children (second-line or greater) and broader **hematological malignancies**, development reached **Phase I** but was **suspended** by late 2024 due to business priorities, with a terminated trial (NCT05077423).[1][7]
- Other names
- huCD33-Bispecific antibody - Y-mAbs TherapeuticshuCD-33-Bispecific antibody - Y-mAbs TherapeuticshuCD 33-Bispecific antibody - Y-mAbs Therapeutics
02
Targets
CD33 (Myeloid cell surface antigen CD33)CD3 (T-cell surface glycoprotein CD3)
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