hucMSC-sEVs

hucMSC-sEVs are small extracellular vesicles (sEVs) derived from human umbilical cord mesenchymal stem cells. These nanoscale membranous vesicles act as carriers of bioactive molecules such as proteins and microRNAs (miRNAs), mediating intercellular communication and exerting therapeutic effects in various disease models. Their mechanisms include delivery of regulatory miRNAs and proteins that modulate cellular pathways involved in tissue regeneration, anti-fibrosis, immunomodulation, anti-tumor activity, and metabolic regulation. For example, they have been shown to inhibit proliferation and metastasis while promoting apoptosis in gastric cancer cells through the transfer of tumor suppressor miRNAs like miR-13896[2][4]. In diabetic kidney disease models, hucMSC-sEVs improve renal function by modulating YAP signaling via 14-3-3ζ protein-mediated autophagy enhancement[5]. They also show promise for liver fibrosis therapy when loaded with specific factors such as BMP7[1], and for renal ischemia-reperfusion injury when enriched with protective miRNAs like miR-202-5p[6]. The broad biological effects of hucMSC-sEVs make them a promising platform for cell-free regenerative medicine.

Other names

human umbilical cord mesenchymal stem cell-derived small extracellular vesiclesHucMSC-sEVshucMSC small extracellular vesicles