HUEXC030 (Orient Pharma Co., Ltd.)

HUEXC030 is an investigational excipient formulation developed by Orient Pharma Co., Ltd., specifically designed to prevent drug-induced liver injury (DILI) in patients undergoing treatment for pulmonary tuberculosis. It is primarily evaluated as an add-on to isoniazid (INH), a first-line anti-tuberculosis medication known for its potential hepatotoxicity. HUEXC030 is a sugar alcohol-based compound that is integrated into isoniazid tablets to mitigate liver damage, particularly in patients with high-risk genotypes for anti-TB drug-induced hepatic injury. Clinical development has reached Phase 2/3, where it is being evaluated for its ability to reduce the incidence of hepatotoxic side effects when used alongside standard anti-TB regimens (including isoniazid, rifampin, pyrazinamide, and ethambutol) without compromising the therapeutic efficacy of the underlying tuberculosis treatment.