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hugan
- Development stage
- Phase 2
- Lead developer
- Sunflower Pharmaceutical Group
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Hugan is a Traditional Chinese Medicine (TCM) formulation primarily used for hepatoprotection and the treatment of liver diseases such as chronic hepatitis B, fatty liver, and early-stage cirrhosis. The standard formulation typically includes extracts from *Schisandra chinensis* (Wuweizi), *Bupleurum chinense* (Chaihu), *Artemisia capillaris* (Yinchen), and *Isatis tinctoria* (Banlangen), supplemented with pig gall powder and mung bean. Hugan works by stabilizing liver cell membranes, promoting liver cell regeneration, and reducing the levels of serum transaminases, specifically alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Beijing Shijia Jiushengyuan Pharmaceutical Technology has conducted Phase 1 clinical trials (e.g., CTR20131792) to evaluate the safety and tolerance of its Hugan Capsule formulation in healthy volunteers, specifically for the indication of hepatitis B.
- Brand names
- Hugan CapsuleHugan Pian
- Other names
- 护肝胶囊护肝片Hugan Tablets
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)CASP3 (Caspase-3)EGFR (Epidermal growth factor receptor)IL1B (Interleukin-1 beta)IL-6 (Interleukin 6)JUN (Transcription factor Jun)TP53 (Cellular Tumor Antigen p53 R175H)VEGFA (Vascular endothelial growth factor A)AMPK (Adenosine monophosphate–activated protein kinase)NF-κB
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