Drug intelligence / Profile preview

hugan

Development stage
Unknown
Lead developer
Sunflower Pharmaceutical Group
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Hugan is a Traditional Chinese Medicine (TCM) formulation primarily used for hepatoprotection and the treatment of liver diseases such as chronic hepatitis B, fatty liver, and early-stage cirrhosis. The standard formulation typically includes extracts from *Schisandra chinensis* (Wuweizi), *Bupleurum chinense* (Chaihu), *Artemisia capillaris* (Yinchen), and *Isatis tinctoria* (Banlangen), supplemented with pig gall powder and mung bean. Hugan works by stabilizing liver cell membranes, promoting liver cell regeneration, and reducing the levels of serum transaminases, specifically alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Beijing Shijia Jiushengyuan Pharmaceutical Technology has conducted Phase 1 clinical trials (e.g., CTR20131792) to evaluate the safety and tolerance of its Hugan Capsule formulation in healthy volunteers, specifically for the indication of hepatitis B.

Brand names
Hugan CapsuleHugan Pian
Other names
护肝胶囊护肝片Hugan Tablets
02

Targets

IL1B (Interleukin-1 beta)JUN (Transcription factor Jun)VEGFA (Vascular endothelial growth factor A)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TP53 (Cellular Tumor Antigen p53 R175H)EGFR T790M (Epidermal growth factor receptor T790M mutant)IL-6 (Interleukin 6)CASP3 (Caspase-3)

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