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Hulisan is a Traditional Chinese Medicine (TCM) herbal formulation primarily developed and utilized by Xi'an Honghui Hospital for the management of orthopedic pain and inflammation. It is designed to promote blood circulation, resolve blood stasis, and alleviate swelling and pain, making it a staple in orthopedic clinical practice in China. The drug is frequently employed as part of a multimodal analgesic strategy to manage postoperative pain in patients undergoing procedures such as total knee arthroplasty (TKA) and to treat chronic symptoms associated with knee osteoarthritis. Clinical research, including registered trials in the Chinese Clinical Trial Registry (ChiCTR), has evaluated its efficacy in reducing the consumption of systemic opioids and improving functional recovery outcomes in orthopedic patients.
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