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human allogeneic adipose-derived mesenchymal adult stem cells
- Development stage
- Unknown
- Lead developer
- Mayo Clinic
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intratumoral, Intrathecal, Intravenous
01
Overview
Human allogeneic adipose-derived mesenchymal adult stem cells are mesenchymal stem/stromal cells (MSCs) isolated from the adipose (fat) tissue of human donors, expanded in culture, and administered to unrelated patients[2][4][5]. These cells exhibit immunomodulatory, anti-inflammatory, and regenerative properties primarily via paracrine signaling—secreting cytokines, growth factors, and trophic factors that support tissue repair and modulate immune responses[2][3][5]. They are considered for treating a range of conditions including neurological disorders, type 1 and type 2 diabetes, Crohn's disease (particularly for complex perianal fistulas), subcutaneous tissue defects, wound healing, degenerative diseases, and certain cancers like glioblastoma[2][3][4][5]. Therapeutic administration may be via local (intratumoral), intrathecal, or intravenous routes[1][4][5]. Mayo Clinic is a noted developer and sponsor of recent clinical trials[4]. The product is not standardized internationally; its characterization and manufacturing vary, with current studies focused on safety, dose finding, and mechanistic profiling[2][4][5].
- Other names
- allogeneic adipose-derived mesenchymal stem cellsallogeneic AD-MSCsallogenic adipose-derived mesenchymal stromal cellshuman allogeneic adipose-derived mesenchymal adult stem cells
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